The effect of endogenous antimicrobial peptides (HNPs1-3 and LL-37) on the course of duodenal ulcer in children

Introduction. Duodenal ulcer in children is characterized by a significant prevalence, frequent development of serious complications and the need for large financial allocations implementation treatment programs. Antimicrobial peptides have an immunomodulatory function can be used as markers severity inflammatory process.Aim. To investigate concentration HNPs 1-3 LL-37 with duodenal ulcer.Methods. A study 47 ulcer, aged 7–18 years, was conducted determination CagA HR antigen feces enzyme-linked immunosorbent assay, levels blood plasma assay on "PrisMatic" IN013 model 4301 analyzer test systems "MyBioSource, Inc.", USA. All underwent complex clinical instrumental laboratory examination (topographic intragastric pH-metry, endoscopic targeted biopsy morphological HP). Results. 76.6% people DU were infected HP. 80% had toxigenic strain In vast majority DU, small ulcerative defects diagnosed. II III degrees activity occurred almost same frequency (44.6% 34% people), while I degree only 21.3% cases. The average level HNP1-3 46.56 ± 8.52 ng/ml, - 269.9 26.53 ng/ml. Direct probable connections between course process established.Conclusion. Elevated found ulcers associated strains Helicobacter pylori. Significantly higher registered severe disease active process, which indicates direct influence antimicrobial pathological process.